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Anti-Epileptogenic Activity of ß-Amino Acids Disclosure Number: IPCOM000004829D
Publication Date: 2001-Jun-26

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Patent/Patent Application:
09/041,371 [+details]


Our novel approach to epilepsy treatment involves preventing the onset of seizures following a brain trauma. Current epilepsy medications target the propogation of hyperexcitability from a seizure focus through the brain. With the described syntheses of substituted ß-amino acids, our target of inhibition of the biochemical pathway that leads to seizure focus development is attained. Molecular designs to face neuromedicinal chemistry challenges such as crossing the Blood-Brain-Barrier, walking the hydrophobicity tightrope, and preventing neurotoxicity will be discussed