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The process for extracting secoisolariciresinol diglucoside oligomer from flaxseed

IP.com Disclosure Number: IPCOM000006769D
Publication Date: 2002-Jan-30

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Takeshi Ikeda


This document is described for extraction and purification of secoisolariciresinol diglucoside (SDG) oligomer from flaxseed. The beneficial effect of SDG was well known. SDG and its mammalian lignan metabolites produced by the intestinal microflora were reported to enhance health by having phytoestrogenic, anticarcinogenic and antiatherosclerotic effects (Axelson et al., Nature 1982 Vol. 298, 659-660). The preventive effects of SDG for breast, prostate, and colon cancer were described elsewhere (Thompson et al., Nutr. Cancer 1996 Vol. 26, 159-165). It is exist that a patent, International Publication No. WO96/30468, described for base-catalysed hydrolysis of SDG oligomer of flaxseed and extracting SDG monomer therefrom. However, SDG oligomer is suitable for natural organic foods depending on avoidance of chemical reaction. Furthermore, SDG oligomer probably includes b-hydroxy-b-methylglutaric acid (HMG) and the joint bioavailability of the SDG and HMG in flaxseed may be preferable to SDG alone (Ford et al., J. Nat. Prod. 2001 Vol.64, 1388-1397). Effective and industrial extracting process for SDG oligomer has been desired. It is, therefore, the main object of the present description to provide an improved process for extracting SDG oligomer from flaxseed, in which water-soluble organic solvents, especially acetone, are used in extraction for not only in large quantities but also inexpensive . The process comprises contacting a substantially oil-free flaxseed meal with water-soluble organic solvents, e.g. a mixture of acetone with water, to extract SDG oligomer and other phenolic derivatives into the solvent and separating residual solids from the solvent containing SDG oligomer. The solvent is concentrated by removing solvent therefrom and the extract containing SDG oligomer is obtained. Thereafter, the extract is suspended a water-soluble organic solvent with water, e.g. about 20-30% acetone, and adsorbed by synthetic adsorb resin. The adsorbed substance are eluted with a water-soluble organic solvent, e.g. acetone, and obtained SDG oligomer at a purity about 28-30%.