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Concept Search - What can I type?
For a concept search, you can enter phrases, sentences, or full paragraphs in English. For example, copy and paste the abstract of a patent application or paragraphs from an article.
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Preparation of 1-[2-Amino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol by hydrogenation of (1-hydroxy-cyclohexyl)-(4-methoxy-phenyl)-acetonitrile in the presence of nickel catalysts.
English (United States)
This text was extracted from a Microsoft Word document.
100% of the total text.
Preparation of 1-[2-Amino-1-(4-methoxy-phenyl)-ethyl]-cyclo-hexanol
is an important intermediate in the synthesis of venlafaxine hydrochloride.
According to patent US4535186 this intermediate is prepared by hydrogenation of
(1-hydroxy-cyclohexyl)-(4-methoxy-phenyl)-acetonitrile in the presence of a
rhodium catalyst. These catalysts provide economical drawbacks because of the
high price of rhodium. It was now found that with cheap nickel catalysts like Raney-nickel,
with or witout pretreatment with a vanadium salt, hydrogenation of
1-[2-Amino-1-(4-methoxy-phenyl)-ethyl]-cyclo-hexanol in >90% yield. The
reaction can be best carried out in an alcohol or dioxan under hydrogen
pressure of 20 to 40 bar. The catalyst may be reused several times after
filtration of the reaction mixture.