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Biotransformation of Glycyrrhizin to Glycyrhizic acid monoglucuronide and Glycyrrhetic acid by Enzymes

IP.com Disclosure Number: IPCOM000011440D
Publication Date: 2003-Feb-20

Publishing Venue

The IP.com Prior Art Database

Abstract

Glycyrrhizin, which shows 170 times sweetness as sucrose, is the major natural sweet compound existing in licorice , and it has been used as the food-additive and medicine. Glycyrhizic acid monoglucurnide and glycyrrhizic acid are derivatives of Glycyrrhizin. The former one shows 1000 times sweetness as sucrose and the later one has better clinical effects, such as anti-inflammatory, analgesic and antiviral than the other two. VISCOZYME and GAMANASE, two commercial enzyme preparations from NOVOZYMES A/S, Krogshoejvej 36, DK-2880 Bagsvaerd, Denmark, can deglycosylate GL into GAMG and GA respectively at a high efficiency under gentle conditions. VISCOZYME is a multi-enzyme preparation obtained from Aspergillus aculeatus, it contains arabanase, cellulase, b-glucanase, hemicellulase, xylanase,pectinase and beta-glucuronidase activity. GAMANASE is a 1,4--D-Mannan mannanohydrolase obtained from Aspergillus niger. it also contained beta-glucuonidase activity.