Orodispersible pharmaceutical formulaions for antipsychotic agent
Publication Date: 2003-Mar-14
The IP.com Prior Art Database
Orodispersible Pharmaceutical Formulations for Antipsychotic Agent
Solid orodispersible dosage form capable of releasing 1mg to 10 mg of the active pharmaceutical ingredient represented by the chemical formula shown in Figure 1, optionally in the form of its salts or hydrates, to human patients following administration by disintegrating in the oral cavity may contain 0.1% to 5% of the active pharmaceutical ingredient represented by the chemical formula shown in Figure 1, optionally in the form of its salts or hydrates, 35% to 55% of a sugar-type diluent, 1% to 4% of a naturally occurring clathrate e.g. betadex, 30% to 50% of a diluent selected from microcrystalline celluloses, 0.1% to 2% of an internally cross-linked sodium carboxy methylcellulose disintegrant and optionally other conventional tabletting excipients selected from known lubricants, sweeteners, opacifiers, glidants and/or anti-caking agents in amounts from 0.1% to 2%, said dosage form being prepared by combining complexed active ingredient, with mixed diluents, granulating and compressing lubricated granules to a hardness of 3 to 4 kg/cm2.