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Small-Molecule Modulation of Read-Through (SMMRT): Modification of 2-Phenoxyacetanilides to Improve Solution Solubility. Richard G. Wilde et al.

IP.com Disclosure Number: IPCOM000019283D
Publication Date: 2003-Sep-09

Publishing Venue

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Abstract

Heterocyclic groups (furans, benzofurans and benzopyrans) were surveyed as potential surrogates for the ether likage of the phenoxyacetanilide series. Several benzofurans were equipotent with compound 1. Monocyclic furans were much less potent. A furan had lower buffer stability of the amide bond compared to compound 1, but higher serum stability. A benzofuran of similar buffer stabiity and slightly better serum stability than compound 1.