Preparation of Di(2-hydroxybenzylamines) by Reduction of Disalicylimines
Publication Date: 2004-Jun-22
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Di(2-hydroxybenzylamines), II, can be prepared from the corresponding disalicylimines, I, by either borohydride reduction or hydrogenation with heterogeneous transition metal catalysts. In either case, the disalicylimines can be prepared in situ from the amine and substituted salicyladehyde and then reduced. The addition of acids, such as acetic acid, or bases, such as cesium carbonate, can improve the performance of the heterogeneous metal catalyst system.