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Cleavage of Oligonucleotides from Solid Supports

IP.com Disclosure Number: IPCOM000029826D
Publication Date: 2004-Jul-14

Publishing Venue

The IP.com Prior Art Database

Abstract

This disclosure describes processes for the cleavage of synthetic oligonucleotides from solid supports. These processes include an in-line method in which the cleavage reagents are pumped through the solid support bearing the oligonucleotide and contained in a column or similar vessel within in a reactor. The benefits of carrying out such in-line cleavage processes at elevated temperature are described.