Cleavage of Oligonucleotides from Solid Supports
Publication Date: 2004-Jul-14
The IP.com Prior Art Database
This disclosure describes processes for the cleavage of synthetic oligonucleotides from solid supports. These processes include an in-line method in which the cleavage reagents are pumped through the solid support bearing the oligonucleotide and contained in a column or similar vessel within in a reactor. The benefits of carrying out such in-line cleavage processes at elevated temperature are described.