Non-Linear Crystalline Compounds
Original Publication Date: 1983-Jul-01
Included in the Prior Art Database: 2005-Feb-07
It has been found that commercially available 1-furo-2-amino-4-nitrobenzene is easily converted in two or three steps into a group of compounds of which many are strongly non-linear in crystalline form. In a typical preparation the 2-amino group is first derivatized to facilitate subsequent nucleophilic displacement of fluorine. The new 2-substituents which result include acetamide, propionamide, trifluoroacetamide, formamide, t-butoxycarbonylamino, ureido, sulfonamide, and the like. The 1-fluoro group in these derivatives is then replaced by some nucleophile, usually an amine. If desired, the original 2-amino group may be regenerated from these 1-donor substituted materials by hydrolysis.