Browse Prior Art Database

PROCESSES FOR SYNTHESIZING N-(CARBAMOYLMETHYL-4-PHENYL-2-PYRROLIDINONE AND INTERMEDIATES THEREOF

IP.com Disclosure Number: IPCOM000204395D
Publication Date: 2011-Feb-23
Document File: 2 page(s) / 18K

Publishing Venue

The IP.com Prior Art Database

This text was extracted from a PDF file.
This is the abbreviated version, containing approximately 70% of the total text.

Page 01 of 2

PROCESSES FOR SYNTHESIZING N-(CARBAMOYLMETHYL-4-

PHENYL-2-PYRROLIDINONE AND INTERMEDIATES THEREOF

    N-(Carbamoylmethyl-4-phenyl-2-pyrrolidinone, having the following structure:

(This page contains 00 pictures or other non-text object)

is used for the treatment of encephalopathic conditions.

    Described hereinafter, is a process for the preparation of N- (Carbamoylmethyl-4-phenyl-2-pyrrolidinone.

The process can be illustrated by the following scheme:

IV

wherein R, is an alkyl group selected from C1-6 straight or branched chain carbon atoms.

The above process comprises:

a) reducing a mixture of compound of formula (IV) and aryl or alkyl glyoxalate/glyoxallic acid with suitable reducing agent, and further;

b) adding ammonia to the compound obtained from step (a) to produce N- (Carbamoylmethyl-4-phenyl-2-pyrrolidinone.

Step (a), can be optionally done in the presence of an acid catalyst at ambient

temperature.

An ambient temperature for above reaction may be defined as, temperature, on which reactant may completely converted into product.

The reducing agent may be selected from Raney Ni, Sodium borohydride, Lithium aluminium hydride, hydrazine, diisobutyl aluminum hydride, Lindlar catalyst, Adam's catalyst and Palladium.

1

(This page contains 01 pictures or other non-text object)

V



Page 02 of 2

An acid for the reaction can be used in catalytic amount. The acid catalyst may be selected from methane sulphonic acid, p-toluenesulphonic acid, pyridinium p-toluene sulphonic a...

Processing...
Loading...