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Instrument for treating tumours

IP.com Disclosure Number: IPCOM000230156D
Publication Date: 2013-Aug-23
Document File: 6 page(s) / 188K

Publishing Venue

The IP.com Prior Art Database



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The proposal relates to treatment of tumours. The proposal also relates to an invasive instrument for treatment of tumours.

According to the proposal it is proposed to combine high-intensity ultrasound (HIFU) hyperthermia with TF ablation. The invasive instrument according to the proposal comprises a HIFU transducer array as well as a MW antenna.

The proposal enables to combine HIFU generated hyperthermia with a small focal spot with heating of a larger area by way of the RF ablation. Preferably the application of hyperthermia is combined with radiotherapy

A combined therapy method for prostate is proposed, which uses a combined HIFU and Microwave antenna arrays in one package. The device can be used for hyperthermia in combination with radiation therapy but also for local ablation of feeding vessel structure during one MRI session. Combined with an optimized endorectal prostate coil design, highest SNR required for real time MRI monitoring and calibration is guaranteed.

Hyperthermia has been extensively studied as an adjuvant to radiation therapy in the management of local-regional metastases and has been shown to improve the results of radiation therapy for the treatment of some recurrent and progressive tumours.

The combination of hyperthermia and radiotherapy may increase the effectiveness of radiotherapy alone in the palliative treatment of some tumors. Hyperthermic temperatures increase blood circulation in tumors as a response to the stimulus of heat. Tumor tissues that have low blood flow are resistant to radiotherapy but are sensitive to hyperthermia, while tumor tissues with high blood flow are sensitive to radiotherapy making the two treatments complementary.

Mild hyperthermia (40-45°C) is a proven adjuvant for radiotherapy and chemotherapy. Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) can non-invasively heat solid tumours under image guidance. Low temperature-sensitive liposomes (LTSLs) release their drug cargo in response to heat (>40°C) and may improve drug delivery to solid tumours when combined with mild hyperthermia [1].

The proposed MR-HIFU-MW therapy method in combination with a software algorithm treats the complexity of temperature regulation and combined heating sources, resulting in accurate and homogeneous heating within the targeted region. Calibration and motion compensation of the MR compatible device is achieved via integrated MR markers and integrated MR antenna.

 A HIFU beam typically has small focal spot. For homogeneously heating larger areas of tissue, a step-and-shoot mode has to be implemented resulting in significantly longer treatment times.

 Effective hyperthemia requires fast heating of a larger target area
 Ablation and hyperthermia application currently needs to be done in different

   sessions and with dedicated systems.
 Radiation therapy with simultaneous application of hyperthermia is currently not


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A combined thera...