The following operators can be used to better focus your queries.
( ) , AND, OR, NOT, W/#
? single char wildcard, not at start
* multi char wildcard, not at start
"..." literal
Examples:
(Cat? OR feline) AND NOT dog?
Cat? W/5 behavior
(Cat? OR feline) AND traits
Cat AND charact*This guide provides a more detailed description of the syntax that is supported along with examples.
This search box also supports the look-up of an IP.com Digital Signature (also referred to as Fingerprint); enter the 72-, 48-, or 32-character code to retrieve details of the associated file or submission.
For a concept search, you can enter phrases, sentences, or full paragraphs in English. For example, copy and paste the abstract of a patent application or paragraphs from an article.
Concept search eliminates the need for complex Boolean syntax to inform retrieval. Our Semantic Gist engine uses advanced cognitive semantic analysis to extract the meaning of data. This reduces the chances of missing valuable information, that may result from traditional keyword searching.
The IP.com Prior Art Database
Undisclosed
English (United States)
Page 01 of 3
Crystalline form of
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine (previously referred in IPCOM000234585D as compound A-8) may be an intermediate in the synthesis of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6- quinazolinyl]-4(dimethylamino)-2-butenamide. Disclosed herein after is acrystalline Form VII of compound A-8.
Crystalline Form VII of Compound A-8
The crystalline form VII of Compound A-8 is characterized by an X-ray powder diffraction pattern having peaks at: 5.9, 13.1, 15.2, 17.8, 19.3, 20.4, 21.5, 24.6 and 25.1 degrees two theta ± 0.2 degrees two theta; and/or an X-ray powder diffraction pattern as depicted in Figure 1; and/or an FTIR spectrum as depicted in Figure 2.
Intensity (counts)
5000
4000
3000
2000
1000
0
5
10
15
20
25
30
35
2Theta (°)
Figure 1. PXRD pattern of crystalline (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3- yloxy)quinazoline-4,6-diamine form VII in mixture with form VI.
Page 02 of 3
Figure 2. FTIR spectrum of crystalline (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3- yloxy)quinazoline-4,6-diamine form VII in mixture with form VI.
Experimental:
PXRD method:
After being powdered using mortar and pestle, samples were applied directly on a silicon plate holder. The X-ray powder diffraction pattern was measured with a Philips X'Pert PRO X-ray powder diffractometer, equipped with a Cu irradiation source = 1.54184 Ǻ (Ǻngström), X'Celerator...
