Crystalline form of (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine
Publication Date: 2014-Oct-23
Publishing Venue
The IP.com Prior Art Database
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The IP.com Prior Art Database
Undisclosed
English (United States)
Page 01 of 3
Crystalline form of
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine (previously referred in IPCOM000234585D as compound A-8) may be an intermediate in the synthesis of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6- quinazolinyl]-4(dimethylamino)-2-butenamide. Disclosed herein after is acrystalline Form VII of compound A-8.
Crystalline Form VII of Compound A-8
The crystalline form VII of Compound A-8 is characterized by an X-ray powder diffraction pattern having peaks at: 5.9, 13.1, 15.2, 17.8, 19.3, 20.4, 21.5, 24.6 and 25.1 degrees two theta ± 0.2 degrees two theta; and/or an X-ray powder diffraction pattern as depicted in Figure 1; and/or an FTIR spectrum as depicted in Figure 2.
Intensity (counts)
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2Theta (°)
Figure 1. PXRD pattern of crystalline (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3- yloxy)quinazoline-4,6-diamine form VII in mixture with form VI.
Page 02 of 3
Figure 2. FTIR spectrum of crystalline (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3- yloxy)quinazoline-4,6-diamine form VII in mixture with form VI.
Experimental:
PXRD method:
After being powdered using mortar and pestle, samples were applied directly on a silicon plate holder. The X-ray powder diffraction pattern was measured with a Philips X'Pert PRO X-ray powder diffractometer, equipped with a Cu irradiation source = 1.54184 Ǻ (Ǻngström), X'Celerator...