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A process for preparing 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

IP.com Disclosure Number: IPCOM000240179D
Publication Date: 2015-Jan-09
Document File: 1 page(s) / 20K

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A process for preparing 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-

tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c]pyridine-3-carboxylic acid ethyl ester (24,2 g) was dissolved in dimethylformamide (121 ml) and formamide (29,6 ml). Sodium ethoxide solution in ethanol (23,1 ml, 21 wt %) was added and the mixture was agitated for 2 h. Water (484 ml) was added and the resulting slurry was cooled to 5 ºC and agitated for 12 h. The product was filtered and washed with water (130 ml). After drying in a vacuum oven at 50 ºC, 21,0 g (92% yield) of an off white solid, identified by HPLC as 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H- pyrazolo[3,4-c]pyridine-3-carboxylic acid amide, was isolated.