DEVICE AND TECHNIQUES FOR COMBINING MAGNETIC RESONANCE METABOLIC IMAGING AND HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF PROSTATE CANCER
Publication Date: 2015-Apr-10
The IP.com Prior Art Database
The disclosed invention provides a device and technique for combining magnetic resonance (MR) metabolic imaging and high-intensity focused ultrasound (HIFU) treatment of prostate cancer. The technique provides rapid assessment of tumor aggressiveness and response to therapy by detecting changes of cellular metabolism. The device proposed here combines a dual-tuned 1H and 13C radiofrequency (RF) coil and HIFU module into the same endorectal device. The device enables high resolution, state of the art 1H MR imaging and 13C hyperpolarized MR metabolic imaging of prostate for localizing, defining and staging of tumor prior to HIFU treatment. The device also allows metabolic assessment of cancer following treatment all in one exam, inside the MR scanner.
The present invention relates generally to prostate cancer treatment and imaging assessment and more particularly to a device and technique to combine magnetic resonance (MR) metabolic imaging and high-intensity focused ultrasound treatment of prostate cancer.
Generally, endorectal radio frequency (RF) coils are used routinely for 1H magnetic resonance imaging (MRI) of prostate for characterization or localization of prostate tumors and benign hyperplasia. In a conventional technique, real time MR metabolic imaging of human prostate is performed in vivo after injection of hyperpolarized [1-13C] pyruvate.
Another conventional technique utilizes an endorectal device for non-invasive treatment of prostate tumors using high intensity focused ultrasound (HIFU) in prostate cancer patients under MR guidance. The technique uses external RF coils to acquire necessary anatomical imaging data for prescribing and monitoring the treatment. However, external RF coils is inferior in terms of sensitivity as compared to endorectal coil by a factor of ~10. As a result, external RF coils may not be sufficient to provide accurate localization and MR temperature measurement of the prostate during MR guided HIFU treatment.
It would be desirable to have an efficient technique to improve MR imaging assessment of the prostate during the prostate HIFU treatment exam.
The disclosed invention provides a device and technique for combining magnetic resonance (MR) metabolic imaging and high-intensity focused ultrasound (HIFU) treatment of prostate cancer. The technique provides rapid assessment of tumor aggressiveness and response to therapy by detecting changes of cellular metabolism.
The technique constructs the disclosed endorectal device that combines a dual-tuned 1H and 13C (or another nucleus) RF coil which is capable of MR imaging of human prostate for both 1H and 13C (or another) nuclei and a HIFU module for thermally ablating prostatic tissues.
The combined endorectal device, when used in a MR scanner, provides state of the art, multi-parametric 1H imaging of prostate as well as hyperpolarized 13C metabolic imaging for localizing, defining and staging of prostate cancer prior to HIFU ablation. The information is used to plan and guide the treatment.
Using the technique, HIFU ablation of the prostate cancer is performed under MR imaging guidance without moving a patient from the scanner or the device from the patient. The endorectal 1H RF coil provides high resolution MR thermal measurement of tissue during treatment. By combining HIFU functionality and RF coil(s) into one endorectal device, MR imaging assessment of the prostate during the prostate HIFU treatment exam is much improved.
Further, the techniqu...