Browse Prior Art Database

Crystalline forms of 1 ethylsulfonyl 3 4 7H pyrrolo 2 3 d pyrimidin 4 yl 1H pyrazol 1 yl azetidin 3 yl acetonitrile baricitinib

IP.com Disclosure Number: IPCOM000244270D
Publication Date: 2015-Nov-27

Publishing Venue

The IP.com Prior Art Database

Related People

Authors:
Balazs Volk Eva Sipos

Abstract

Crystalline forms of baricitinib were found and are described hereinbelow 1 Ethylsulfonyl 3 4 7H pyrrolo 2 3 d pyrimidin 4 yl 1H pyrazol 1 yl azetidin 3 yl acetonitrile baricitinib of the following formula is in Phase III development as a potential treatment for rheumatoid arthritis It is in Phase II development as a potential treatment for psoriasis and diabetic nephropathy The names of the crystalline forms of baricitinib were given based on their appearance temperature As follows the polymorph observed at room temperature has been denoted as the crystalline form of baricitnib at room temperature while the polymorph obtained at high temperature as the crystalline form of baricitinib at high temperature