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Proposition for a Gleason Score measurement protocol Disclosure Number: IPCOM000249899D
Publication Date: 2017-Apr-26
Document File: 1 page(s) / 31K

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Proposition for a Gleason Score measurement protocol

This document aims to provide a solution specific to providing a more accurate and more quantitative Gleason score in prostate cancer. A known scoring classification consists in 5 classes for 5 combinations of Gleason Scores (GS) 3+3; 3+4; 4+3; 4+4; >4+4, the first and second numbers representing the primary and secondary Gleason Grade (GG) of the tumor. However, one may need further refinement of the Gleason scores 3+4 and 4+3 into %GG3+%GG4 vs. %GG4+%GG3.

As a solution, it could be possible to develop an interface which can compute an overall score for the tumor, namely the percentage of cells selected over the total number of cells of the grid. For instance, tumor 1 1 : Gleason Score 3+4; percentage GG3 = 55%; percentage GG4 = 45%. Consequently a discrimination is possible with a tumor 2: Gleason score 3+4, percentage GG3 = 95%, percentage 4 = 5%. The two tumors may have very different prognosis and outcomes with significant consequences for the patient.

The overall Gleason Score may also be based on several tumor samples from an individual patient, by totalizing the same individual scores over the samples and computing a an overall percentage. For instance in the example below 3 samples (e.g., a biopsy) were investigated for Gleason Grade 3 or 4. The pathologist indicates the number of cells that are GG3 or GG4 in all samples.

Sample 1 Sample 2 Sample 3 Total number of cells with GG3 or GG4

Percentage of GG3 or GG4