The following operators can be used to better focus your queries.
( ) , AND, OR, NOT, W/#
? single char wildcard, not at start
* multi char wildcard, not at start
(Cat? OR feline) AND NOT dog?
Cat? W/5 behavior
(Cat? OR feline) AND traits
Cat AND charact*
This guide provides a more detailed description of the syntax that is supported along with examples.
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Concept Search - What can I type?
For a concept search, you can enter phrases, sentences, or full paragraphs in English. For example, copy and paste the abstract of a patent application or paragraphs from an article.
Concept search eliminates the need for complex Boolean syntax to inform retrieval. Our Semantic Gist engine uses advanced cognitive semantic analysis to extract the meaning of data. This reduces the chances of missing valuable information, that may result from traditional keyword searching.
This text was extracted from a Microsoft Word document.
At least one non-text object (such as an image or picture) has been suppressed.
This is the abbreviated version, containing approximately
55% of the total text.
present disclosure relates to an improved process for the preparation of
Etoricoxib or its pharmaceutically acceptable salts thereof. The present disclosure
also relates to process for the preparation of Etoricoxib polymorphic form-I.
Etoricoxib is a
potent and selective COX-2 inhibitor, which is effective in the management of
chronic pain in rheumatoid arthritis, osteoarthritis and other COX-2 mediated
disorders. Etoricoxib is sold by Merck Sharp & Dohme Limited under the
brand name ARCOXIA®.
designated chemically as 5-chloro-3-[4-methylsulfonyl)
phenyl]-2-(2-methyl-5-pyridinyl) pyridine and is represented by the compound of
present disclosure provides an improved process for the preparation of Etoricoxib.
The present disclosure also relates to process for the preparation of
Etoricoxib polymorphic form-I.
butoxide (42.5 g) added to 2-(4-Methanesulfonylphenyl)-1-(6-methyl-pyridin-3-yl)
ethenone (100 g) in Tetrahydrofuran at 5±5°C under nitrogen atmosphere. The
mixture temeperature raised to 18±3°C and stir for 30-60 min. Chloro-1,3-bis(dimethylamino)-trimethiniumhexafluorophosphate
(111.5g) was added at 18±3°C, stirred for 90-120 min. Dimethylformamide (50 ml)
was added and reaction mixture was poured into acetic acid (207.5g) and
trifluoro acetic acid(32.5g) in Tetrahydrofuran (50ml) at 5±5°C. The reaction
mixture was stirred for 60-90 min at 18±3°C. Ammonia solution (275 ml) was